Menu
Log in


Canadian Society of

Pharmacology and Therapeutics

Log in

Glossary of Pharmacology 

IrReversible antagonist

Definition: 
An antagonist that binds to the receptor in an irreversible manner. The interaction between the antagonist and the receptor is tight (mostly covalent) and therefore the antagonism is insurmountable at any concentration of the agonist.  

Example:

Phenoxybenzamine is an antagonist of the α-adrenergic receptors in the blood vessels, and it forms a covalent bond with the receptors. Thus, it irreversibly blocks the vasoconstrictive action of catecholamines leading dilation of the blood vessels and reduction in blood pressure.

Return to Glossary

Copyright© 2020

Canadian Society of Pharmacology and Therapeutics (CSPT)

All rights reserved.

Email: info@pharmacologycanada.org


Powered by Wild Apricot Membership Software