Adverse drug event
Definition:
An Adverse Drug Event (ADE) is defined as “an injury resulting from medical intervention related to a drug, which includes errors in administration (Bates et. al. (1995) JAMA 274; 29-34). Thus ADEs are a broad range of harms which include Adverse Drug Reactions (which are harms that occur when the correct drug is used in the correct dose and given via the correct route) but also drug errors in which an incorrect drug is given, a drug is given in overdose or a drug is given via the wrong route.
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Relevance:
ADEs are unfortunately extremely common and as with Adverse Drug Reactions are a major problem for patients, families, health care providers, health care systems, government and industry. Adverse Drug Events and medical errors are believed to be the third commonest cause of death in the United States with 100,000 Americans a year dying as a consequence of an ADE/medical error. Adverse Drug Events appear to be more common among certain vulnerable populations such as very young children and older adults on multiple medications and special care must be taken when prescribing to these populations. Thus an understanding of the mechanism and importance of Adverse Drug Events is important for all health care providers.
There are a number of potential approaches to reduce the risk of ADEs including the systems based approaches such as electronic prescribing systems. While these approaches can reduce certain types of ADE they may also be associated with a risk for other types of ADEs.
Examples of Adverse Drug Reactions:
Drug
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Adverse Drug Event
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Mechanism
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Morphine
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10 fold error
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Error in calculating drug dose with the patient receiving 10 times the correct dose of intravenous morphine causing decreased level of consciousness and respiratory depression
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Glyburide and Glipizide
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Inadvertent substitution of one drug for another
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Both drugs are sulfonylureas used to treat diabetes with similar names; however they have different doses and dosing schedules and using one drug in the wrong dose can produce adverse effects such as hypoglycaemia
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Midazolam
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Mistaken administration of an oral formulation by the intravenous route, i.e. injection into the blood of a formulation intended to be taken by mouth
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Increased sedative effect and reduced level of consciousness as midazolam has 50% bioavailability; also potential for infection and to effects of injected excipients
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Teaching tips:
Considerations around using Adverse Drug Events to inform teaching include:
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Understanding how Adverse Drug Events occur in the context of usual prescribing practices
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Appreciating the mechanism by which Adverse Drug Events produce harm, including the consequences of overdoses
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Communicating clearly with patients and families as when an Adverse Drug Event has occurred and how it was addressed
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Considering systems-based approaches to reducing the risk of preventable Adverse Drug Events
Suggested articles on this topic:
- Wittich CM, Burkle CM, Lanier WL Medication Errors: An overview for clinicians Mayo Clin Proc 2014;89:1116-1125
- This manuscript reviews common issues leading to medication errors
- Makary M, Daniel M. Medical error – the third leading cause of death in the US. BMJ 2016; 353: 2139.
- This manuscript identifies medical errors as a major cause of death in the US and by extension other countries
- Tariq RA, Vashisht R, Sinha A et al. Medication dispensing errors and prevention. https://www.ncbi.nlm.nih.gov/books/NBK519065/#!po=2.17391.
- This is a review of medication errors including consideration on how they occur and how to prevent them
Linked terms: Adverse Drug Reactions, Drug Safety, Pharmacovigilance, Drug Allergy, Side Effects
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