PBPK Modeling for Human Drug Disposition: From Mechanistic Insights to Clinical Dosing

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“PBPK Modeling for Human Drug Disposition: From Mechanistic Insights to Clinical Dosing ”

Hear from

Toshiaki Tsuchitani, PhD

Keio University

"Characterizing Apixaban Pharmacokinetics via PBPK Modeling: The Critical Roles of Biliary Secretion and Enterohepatic Circulation in Humans"

and 

Samuel Dubinsky, PharmD, PhD

Dalhousie University and Nova Scotia Health

"Ex-vivo to In-vivo Extrapolation: The Use of Physiologically-based Pharmacokinetic Modelling to Determine Drug Dosing in Critically Ill Patients Receiving Extracorporeal Therapy"

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