Glossary of PharmacologyPhase III clinical TrialDefinition:The Phase III clinical trial is the final pre-approval phase of clinical studies and involves comparing the new drug to either a placebo treatment or to the current standard of care. Phase III trials involve larger groups of patients, which can range from several hundred up to 30,000 people. The subjects are assigned randomly to the drug or to the control group and are blinded as to whether they receive the new drug or the control treatment. The aim of this trial is to confirm the effectiveness of the drug/treatment, ideally compared to current “gold standard” treatment, and to continue to monitor its adverse effects.Relevance:
Teaching Tips: Why do Researchers do Different Kinds of Clinical Studies? https://www.nih.gov/sites/default/files/health-info/clinical-trials/infographic-why-researchers-different-kinds-clinical-studies.pdf Linked terms: Generalizability, Sample population, Phase I clinical trial, Phase II clinical trial, Phase IV clinical trial, Clinical trial, Placebo, LOAEL (Lowest Observed Adverse Effect Level), NOAEL (No Observed Adverse Effect Level) Resources: U.S. Department of Health and Human Services. (2022, October 3). The basics. National Institutes of Health. https://www.nih.gov/health-information/nih-clinical-research-trials-you/basics#:~:text=Phase%20I%20trials%3A%20Researchers%20test,safety%20and%20identify%20side%20effects |